Abstract: With the large-scale mining disturbance of the thick and large orebody in the west of Baixiangshan Iron Mine, the hydrogeological structure of the mining area changes in spatio-temporal evolution, and Qingshan River water will become the main water-filling source, and through the rock displacement dislocation fissures, large-scale water-conducting structures pour back into the mine, causing devastating disasters to the mine and the surrounding geological environment. Based on the fine and transparent exploration study on the characteristics of different water disaster factors and the water channel of the mine, combined with the previous research results of water control, the integrated safe and reliable water control technology scheme for drainage and plugging avoidance, which meets the actual needs of the mine, has been formulated to solve a series of key safety and technical problems caused by the mining of thick and large orebodies, especially in the west of China, the goal of green development and utilization of mine resources has been realized.