Benzyl acetate

Benzyl acetate is an important synthetic fragrance that is widely used in the food and cosmetic industries, but it is also an important solvent that can dissolve a variety of compounds such as cellulose acetate, dyes, oils and printing inks, and is used in the textile and dye industries.

Add 0.5 g benzyl chloride and ammonium acetate (0.77 mmol) together to 5 ml glycerin. After mixing, the reaction mixture is heated to 80°C in an oil bath. Let the reaction run for 1 hour. Let the mixture cool. Separate the product. After cooling, the mixture was extracted with 5mL of petroleum ether. Concentrate the organic phase under reduced pressure. The crude oil was analyzed by gas chromatography with HP-I column. The title compound benzyl acetate was obtained by evaporation under reduced pressure.

The synthetic route of benzyl acetate is shown

According to method 1 of ester content determination method (OT-18). The sample size was 900mg. Equivalent factor (e) in the calculation or determined by gas chromatography (GT-10-4) with a non-polar column. It is rapidly hydrolyzed and metabolized in animals.
Adl 0~5mg/kg(FAO/WHO, 1994).
LD ₅₀2490-3696 mg/kg(rat, oral). FEMA(mg/kg) : Soft drinks 7.8; Cold drinks 14; Candy 34; Baked goods 22; Pudding 23; Gum 760.
Moderation is limited (FDA§ 172.515, 2000). Colorless oily liquid with jasmine type aroma. It is almost insoluble in water and miscible with most solvents such as ethanol and ether. It is used to prepare jasmine fragrance and soap fragrance GB 2760--1996 specifies that the use of edible spices is temporarily permitted. Mainly used for preparing jasmine, peach, apricot, raspberry, strawberry, apple, grape, plum, banana, cherry, pear, pineapple, papaya, cream and other flavors. Benzyl acetate is a food flavor that is temporarily allowed to be used in China. It can be used to prepare fruit flavors such as bayberry, apple, pineapple, grape, banana, strawberry, etc. The dosage is according to the normal production needs, generally 760mg/kg in chewing gum; 34mg/kg in candy; 22mg/kg in baked goods; 14mg/kg in cold drinks; 7.8mg/kg in soft drinks. 1. Use of spices. Benzyl acetate is the main component of jasmine and other extracts, and is an indispensable spice in the preparation of fragrant fragrances such as jasmine and elam. Because of its low price, it is widely used in soap and other industrial fragrances. Often used in jasmine, prynne, hosta, moon fragrance and narcissus and other flavors, can also be used in a small amount of pear, apple, banana, mulberry and other edible flavors. 2. Use of solvents Benzyl acetate dissolves 0.23% (by weight) in water and is insoluble in glycerol. But it can be miscible with alcohol, ether, ketone, ester hydrocarbon, aromatic hydrocarbon and so on. It has good dissolving ability to oil, nitrocellulose, cellulose acetate, etc. It can also dissolve rosin, glycerin trirosinate, coumarone resin, etc. Therefore, it is used as a solvent for shellac paint, alkyd resin, cellulose nitrate, cellulose acetate, dyes, fats, printing inks and so on. Esters, synthetic flavors. It is mainly used as a blending spice for jasmine, prynne, hosta, moonshine and other flavors. It is widely used in a variety of fragrances because of its enhancing effect on the fragrance of flower and fantasy fragrances and its low price. 1. Benzyl alcohol and acetic acid are used as raw materials to directly esterify benzyl acetate under the catalysis of sulfuric acid, and then the finished product is obtained by neutralization, washing and fractionation. 2. Benzyl acetate was synthesized from chlorobenzyl and sodium acetate in the presence of pyridine and dimethylaniline catalysts. Then the finished product is washed and distilled. Benzyl acetate exists naturally in ylang-ylang oil, neroli oil, hyacinth oil, tuberose oil and gardenia oil, and is generally prepared by the following methods for industrial production.
Under the catalysis of sulfuric acid, benzyl alcohol and glacial acetic acid were mixed and heated to esterify. After the reaction, it was first neutralized with alkali and then washed with water until neutral. After drying with anhydrous calcium chloride, the product is distilled under reduced pressure. A small amount of boric acid is added before distillation so that excess benzyl alcohol, which forms a high boiling point benzyl borate, remains in the still.
CH3COOH+C6H5CH2OH[H2SO4]→CH3CHOOCH2C6H5+H2O
The finished product is made by the reaction of chlorobenzyl with sodium acetate. The chlorine in the product must be removed. The yield of this method can reach 80%.
CH3COONa+C6H5CH2ClCH3COOCH2C6H5+NaCl
1kg benzyl alcohol and 2kg anhydrous sodium acetate were added to 1.2kg acetic anhydride successively, and slowly heated to l00℃. After the reaction was moderate, 40g anhydrous sodium acetate was added, and then reflux reaction was carried out for 8h. After cooling, wash with water, neutralize with 10% NaOH solution, then wash until neutral, and finally dry with anhydrous calcium chloride, and then distill the product under vacuum.
(CH3CO)2+C6H5CH2OH[NaAc]→C3H7COOCH2C6H5+CH3COOH It is produced by heating benzyl chloride and sodium acetate under the catalysis of pyridine, and then purified by distillation.
It is formed by esterification of benzyl alcohol with acetic anhydride or acetic acid and purified by distillation. Flammable liquid Poisoned Oral - rat LD50: 2490 mg/kg; Oral - mouse LD50: 830 mg/kg Skin - Rabbit 100 mg / 24 h moderate In case of open fire, high temperature, strong oxidant more flammable; Combustion produces irritating smoke; The drugs affect a person's respiratory and urinary systems Complete packaging, light loading and unloading; Warehouse ventilated, away from open flame, high temperature, separate from oxidizer Foam, carbon dioxide STEL 5 mg/m3