2-picolinic acid

2 - picolinic acid is an important organic synthesis intermediate, used in the pharmaceutical industry for the preparation of capocaine drugs and neurotropic drugs, widely used in nerve inhibition and local anesthesia; 2 - picolinic acid is the synthesis of a variety of 2 - picolinic acid necessary raw materials, of which 2 - chromium picolinic acid is an important human health care drugs, widely used in human chromium supplement, feed additives, diabetes treatment; 2-picolinic acid can also be used in the preparation of herbicides.

White acicular crystal. Melting point 134-136℃, easily soluble in ice acetic acid, almost insoluble in ether, chloroform and carbon disulfide. Intermediates of organic synthesis. 2-methylpyridine potassium permanganate Rare earth alkali metal chelates; Transition metal complexes for the preparation of picolinato ligands Add 50G2-methylpyridine into 2500ml water, heat and stir, add 90g potassium permanganate, and then add the second 90g potassium permanganate after about 1h. Add 500ml water and continue heating for 2-2.5h until the purple disappears. Let cool, filter out manganese dioxide precipitates and wash in hot water. Concentrate the filtrate under reduced pressure and filter. The concentrated liquid was acidified with concentrated hydrochloric acid to Congo red acid, then evaporated to dry, and boiled with 250ml95% ethanol for reflux for 1h. Filter, filter cake extracted with 95% ethanol, combined with ethanol filtrate and extract, through the dry hydrogen chloride until the crystal begins to precipitate. Cool to 10℃, then pass hydrogen chloride to distillation, filter out picolinic acid hydrochloride, after drying to 43-44g (melting point of hydrochloride 210-212℃).