Collect
Check out my collection
0
Useful +1
Tonegawa Susumu was born in Japan
Nagoya City
, PhD, graduated from
Kyoto University
and
University of California, San Diego
. The second in his family, he became interested in chemistry in high school and later attended Kyoto University, where he received his 1987 award for "discovering the genetic principles of antibody diversity.
Nobel Prize in Physiology or Medicine
[1]
.
- Chinese name
- Sumu Ligonkawa
- Foreign name
- Japanese Hiragana: とねがわ すすむ
- nationality
- Japan
- Ethnic group
- Yamato Nation
- Date of birth
- September 5th, 1939 [2]
- Graduate School
- Kyoto University (BA), University of California, San Diego (MA, PhD)
- occupation
- Scientist
- Major achievement
-
LouisaGrossHorwitz Prize, 1982
1987 Nobel Prize in Physiology and Medicine - Place of Birth
- Japan Nagoya City
- Famous achievement
- Antibody diversity
- Blood type
- Type AB
Sumu Ligonkawa
He was the second child in the family, with an older brother and a younger brother and sister. His father was an engineer in a textile factory in the countryside, and because of his work, he had to rotate between factories, so he spent his childhood in the countryside, fully enjoying the wilderness and freedom of the country. Since his parents believed that education was the greatest asset a parent could give to their children, he became famous in Tokyo
Hibiya University
Enrolled, developed an interest in chemistry in high school, and entered after retaking the exam a year later
Kyoto University
The chemistry Department.
He was born in Japan in 1939
Nagoya
He later attended Hibiya High School in Tokyo. Obtained in 1963
Kyoto University
He received a bachelor's degree in chemistry from the University of Kyoto and went to the University of California, San Diego, for graduate study in molecular biology that same year. He studied genetic transcription of bacteriophages and received his doctorate in 1968. in 1971, he became a molecular biologist at the Institute of Immunology in Basel, Switzerland.
In college, Professor Hiromi Yamada, who taught biochemistry, recommended him to be taught by France
Institut Pasteur
Scientist
Farnsworth Jacobs
(Francois Jacob) and
Jake Monod
In a paper written by Jacques Monod
operon
He developed a strong interest in molecular biology. He graduated from university in 1963
Kyoto University
Virus research institute
He studied molecular biology with Watanabe. Watanabe was one of the few scientists in Japan who had returned from the United States with complete training in molecular biology. But after two months of research, Watanabe told him that if he wanted to learn molecular biology well, the environment in Japan was not good enough, and suggested that he should go to the United States to complete his studies. At that time, the trend in Japan was to go to the United States to do postdoctoral work for a few years after graduating from doctoral programs in Japan, and then return to Japan. Mr. Ligonkawa had planned to follow the same model, but after consideration decided to pursue a doctoral program in the United States.
Ligonkawa joined the institute at a time when immunologists were debating the origins of antibodies. When an organism is infected, it produces certain special proteins to defend against infection. These special proteins are called antibodies. The "germ line" theory says that the genes that make antibodies come from
Genetic code
Part of, while"
Somatic mutation
The "somatic mutation" theory states that the antibody genes themselves recombine to code for a new antibody, so that a small number of genes can produce many variants. Kawakami Ligon demonstrated one by way of a demo
DNA molecule
The mutation and recombination (recombine), or rearrangement, prove the "somatic mutation" theory. This process can produce up to 10 billion antibodies, and Ligenkawa found that the mutated gene segments are separated by strips of DNA that appear to be inactive or uncoded, called introns. He also found that these intragenic regions contained a gene control component called a "enhancer." Susumu Ligonkawa's research on antibody genetics has implications for finding cancer - especially
leukaemia
Lymphoma, etc.
hemocarcinoma
The causes of disease play an important role.
In 1968, he graduated from the University of California, San Diego (under Masaki Hayashi), studying transcriptional regulation of bacteriophil. After staying in the lab for a year as a postdoctoral fellow, he entered in 1969
Salk Institute
Renato Dulbecco's lab
SV40
the
transcribe
Regulate. In the autumn of 1970, on the one hand, due to the expiration of the visa to stay in the United States, on the other hand, due to the introduction of Dulbecco, he entered the Institute of Immunology in Basel, Switzerland (then the director of Niels Kaj Jerne).
"People who dare not take risks, or who only know how to score on exams, are not suited to scientific research."
"The most important talent of a scientist is the capacity for doubt and a good imagination."
